Increasing numbers of people report mood changes that leave them feeling “blue” at some point in their lives, especially in response to every day’s life stressors. This phenomena is especially common among older people and among women.
PS eases negative moods that may occur from time to time in response to life’s stressors
Phosphatidylserine (PS), a naturally-occurring lipid that is found throughout the body, has been clinically shown to improve mood. PS intake has been shown to reduce levels of the stress hormone, cortisol, which naturally occurs as part of the body’s reaction to negative mood changes.
Clinical studies with PS have shown the ingredient to have positive effects on mood (Gindin, Y. The effect of herbal phosphatidylserine on memory and mood The Gerontologist 193, 1 (1993).; More, M. I., Freitas, U. & Rutenberg, D. Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia. Adv Ther 31, 1247-1262, (2014).; Benton, D., Donohoe, R. T., Sillance, B. & Nabb, S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci 4, 169-178 (2001).).–
Cortisol levels are increased in people that are experiencing a low mood. Research has shown that PS intake was linked to reductions in cortisol levels in both blood and saliva (Hellhammer, J. et al. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress 7, 119-126 (2004).; Starks, M. A., Starks, S. L., Kingsley, M., Purpura, M. & Jager, R. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr 5, 11, (2008).; Baumeister, J., Barthel, T., Geiss, K. R. & Weiss, M. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci 11, 103-110, (2008)
Consumption of PS was linked to improved mood in the elderly
Elderly people are often bothered by feelings of occasional gloom. In a double-blind, placebo-controlled study involving 57 elderly subjects who consumed PS (300 mg/day) for 12 weeks, there was almost no development of “winter blues”, while those with no PS intake suffered from a significant reduction in their mood (Gindin, Y. The effect of herbal phosphatidylserine on memory and mood The Gerontologist 193, 1 (1993)).
Effect of Sharp•PS® and DHA (Sharp•PS®®-Silver) on mood in older age
In a pilot study of 18 late-age elderly people experiencing low mood, participants consumed a combination of PS (300 mg/day) and omega-3 (570 mg/day) (Sharp-PS silver) for 12 weeks, and were administered a validated test of their mood status. PS administration was associated with a pronounced mood improvement (Komori, T. The effects of phosphatidylserine and omega-3 fatty acid-containing supplement on late life depression. Mental Illness 7, 7-11 (2015)).
As discussed above, the dose of PS shown to improve moods is 300 mg/day. Clinical studies with PS intake have shown effects after 12 weeks of consumption. Some clinical studies have shown further mood improvement when combining PS with omega-3. While PS is a dietary ingredient that may be useful for those who are in a gloomy state, it is not recommended as a drug for those suffering from Major Depressive Disorder (MDD). MDD is considered a disease and should be treated by trained professionals.